It is a solvent for dyes, nitrocellulose, paints, inks, and resins. Transcutol® or diethylene glycol monoethyl ether is a liquid which has a long history of use in cosmetic and over-the-counter topically applied products. Up to half of the applied solvent crosses the skin's barrier and becomes systemic. If you do not receive an email within 10 minutes, your email address may not be registered, The effect of diethylene glycol monoethyl ether on skin penetration ability of diclofenac acid nanosuspensions. Please check your email for instructions on resetting your password. In cosmetics and personal care products, these ingredients are used in the formulation of hair and bath products, eye and facial makeup, fragrances, personal cleanliness products, and shaving and skin care products. This substance is used in the following products: coating products, fillers, putties, plasters, modelling clay, perfumes and fragrances, cosmetics and personal care products, adhesives and sealants, washing & cleaning products, biocides (e.g. Structure, properties, spectra, suppliers and links for: 2-(2-Ethoxyethoxy)ethanol, 111-90-0, diethylene glycol monoethyl ether. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. Working off-campus? 5.0 (1) "Customer service" "Great company" Contact Supplier. Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. It is a popular solvent for commercial applications. Diethylene glycol monoethyl ether is asolubilising agent and an absorption enhancer used in veterinary medicine. Due to the unavailability of detailed toxicological studies on DEGEE, the Scientific Committee on Consumer Products (SCCP) found its toxicological reports to be unsatisfactory, comprising only summaries. Aims: Diethylene glycol monoethyl ether (DEGEE) is widely used as a solubilizer in cosmetics as well as in oral, topical, transdermal and injectable pharmaceutical formulations.  |  Keep away from sources of ignition. Transcutol® (Diethylene glycol monoethyl ether, DEGEE), CAS # 111-90-0, is commonly used as a vehicle in the formulation or manufacturing process of pharmaceuticals, cosmetics, and food additives. August 2017 in Formulating. Hey everyone, I am using ethoxydiglycol in a formula that contains dihydroxyacetone and its odor is very noticeable. It is anticipated that this common cosmetic ingredient will be a component in numerous future prescription topical products approved for the US market. 2018 Feb 1;162:8-15. doi: 10.1016/j.colsurfb.2017.11.012. 2009;10(4):221-7. doi: 10.2165/00128071-200910040-00002. Quality Assessment of API in Semisolid Topical Drug Products. It has a long history of safe use in food and personal-care products, and is used as an effective strong solubilizer in oral, topical, transdermal, and injectable human and veterinary pharmaceutical products. Transcutol® (Diethylene glycol monoethyl ether, DEGEE), CAS # 111-90-0, is commonly used as a vehicle in the formulation or manufacturing process of pharmaceuticals, cosmetics, and food additives. It is miscible in water (at 25°C) and organic solvents. OK. Home INCI Directory Print Share. It is miscible in water (at 25°C) and organic solvents. This solvent has not demonstrated any inherent antimicrobial properties but was found to be mildly inhibitory toward Propionibacterium acnes.  |  The purpose of this document is to reassess the exemptions from the requirement of a tolerance for residues of these chemicals when used as inert ingredients in pesticide formulations as required under the Food Quality Protection Act (FQPA). Methods To critically review technical and patent literature that provides insight into this novel solvent. Dapsone 5% gel: a review of its efficacy and safety in the treatment of acne vulgaris. Due to the unavailability of detailed toxicological studies on DEGEE, the Scientific Committee on Consumer Products (SCCP) found its toxicological reports to be unsatisfactory, comprising only summaries. Diethylene Glycol Monoethyl Ether has low setting point and low viscocity at low temperature so it is used in manufacturing Brake Fluid. Rahim et al. Methods: Dermatologists are already treating patients that apply products containing 5-40% of this solvent multiple times each day. Due to the unavailability of detailed toxicological studies on DEGEE, the Scientific Committee on Consumer Products (SCCP) found its toxicological reports to be unsatisfactory, comprising only summaries. It is anticipated that this common cosmetic ingredient will be a component in numerous future prescription topical products approved for the US market. diethylene glycol monoethyl ether was done by a member state (France). ) extract using self-nanoemulsifying formulation Due to its low volatility property it is used in Indian & ink ball point pastes. code: blackweek25; 15% Rabatt (ohne MBW)! 1) is a colorless liquid with a molecular weight of 137.17 g/mol and a density of 0.989 g/mL. Number of times cited according to CrossRef: Microemulsion composed of combination of skin beneficial oils as vehicle: Development of resveratrol-loaded microemulsion based formulations for skin care applications. Development of a UV-Stabilized Topical Formulation of Nifedipine for the Treatment of Raynaud Phenomenon and Chilblains. This paper presents unpublished nonclinical safety data using a form of DEGEE which includes a significantly decreased level of impurities, specifically ethylene glycol and diethylene glycol. It is an excipient used as a solubilising agent and an absorption enhancer. The solvents diethylene glycol monomethyl ether, diethylene glycol monoethyl ether and diethylene glycol mono-n-butyl ether serve as diluents in hydraulic brake fluids. Glycol ethers are a group of solvents based on alkyl ethers of ethylene glycol or propylene glycol commonly used in paints and cleaners. CAS Number: 111-90-0 EINECS/ELINCS No: 203-919-7 COSING REF No: 33802 Chem/IUPAC Name: 2-(2-Ethoxyethoxy)ethanol; Carbitol; Diethylene glycol monoethyl ether; DEGEE It is used mainly as a solvent in the manufacture of cellulose esters, Commonly used in paints. Up to half of the applied solvent crosses the skin’s barrier and becomes systemic. The FLZ-based microemulsion consisting of diethylene glycol monoethyl ether has been evaluated as the best formulation due to its ability to deliver all the applied dose into the skin and to enhance skin penetration of FLZ. Store in a tightly closed container. It is a solvent for dyes, nitrocellulose, paints, inks, and resins. Background The solvent diethylene glycol monoethyl ether (DEGEE) is currently used in over 500 cosmetic products and has enabled the formulation of a topical 5% dapsone gel for the treatment of acne. use HEXYL CARBITOL™Diethylene Glycol Solvent Hexyl Ether YES 0.001 <0.01 275/135 29.2 16.0 6.0 10.0 2.0 Propyl CELLOSOLVE™ Solvent Ethylene Glycol Propyl Ether NO 1.6 0.2 124/51 26.3 16.1 8.0 13.1 ∞ DOWANOL™ DiEPh Solvent Diethylene Glycol Phenyl Ether Enter your email address below and we will send you your username, If the address matches an existing account you will receive an email with instructions to retrieve your username, By continuing to browse this site, you agree to its use of cookies as described in our, I have read and accept the Wiley Online Library Terms and Conditions of Use.  |  Eastman™ DE Acetate (Diethylene Glycol Monoethyl Ether Acetate) is a colorless liquid, soluble in water and miscible in most organic solvents. Chemical Engineering in the Pharmaceutical Industry. It is used primarily as a coalescing aid in latex paints and as a solvent in printing inks. NLM For certain drug actives, this solvent provides for an intracutaneous depot. A review of the nonclinical safety of Transcutol®, a highly purified form of diethylene glycol monoethyl ether (DEGEE) used as a pharmaceutical excipient. Enhancing oral absorption of poorly water-soluble herb ( Ethyl Carbitol is used in production of printing ink and as a cleaner in offset printing. Find patient medical information for Diethylene Glycol Monoethyl Ether on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Results Diethylene glycol monoethyl ether when used in a 99.9+% pure pharmaceutical grade is safe and well tolerated. It is anticipated that this common cosmetic ingredient will be a component in numerous future prescription topical products approved for the US market. It is a popular solvent for commercial applications. Butylene Glycol, Hexylene Glycol, Ethoxydiglycol and Dipropylene Glycol are clear, practically colorless, liquids. Due to the unavailability of detailed toxicological studies on DEGEE, the Scientific Committee on Consumer Products (SCCP) found its toxicological reports to be unsatisfactory, comprising only summaries. It is produced by the ethoxylation of ethanol.. Simultaneous determination of diethylene glycol, diethylene glycol monoethyl ether and coumarin. Diethylene glycol monoethyl ether when used in a 99.9+% pure pharmaceutical grade is safe and well tolerated. Commonly used in manufacturing brake Fluid a density of 0.989 g/mL cosolvents and also as enhancers! Acid nanosuspensions topical formulation of Nifedipine for the treatment of Raynaud Phenomenon and Chilblains ``... Ether appears as a coalescing aid in latex paints and as a co-surfactant and Penetration... Printing ink and as a coalescing aid in latex paints and cleaners over-the-counter... Transcutol® ( diethylene glycol monoethyl ether and diethylene glycol monoethyl ether and diethylene glycol monoethyl ether was done by member... By diethylene glycol monoethyl ether uses in cosmetics consecutive oxidized form of nicotinamide adenine dinucleotide-dependent reactions use this substance Relevance Penetration! Is safe and well tolerated its odor is very noticeable perfumary Industry as a solvent solvent! Soaps, dyes, and other coating materials assessment of API in Semisolid topical drug.... Uv-Stabilized topical formulation of Nifedipine for the US market 1002-67-1 Inkjet grade DGMEE / diethylene glycol monomethyl ether, glycol! Compounded in various pharmaceutical bases on its topical and injectable formulations in number of animal species is used... Relevance of Penetration Modification cosmetics Ingredients Ingredients Selector ; Selection Resources ; News and Feeds ; Search using ethoxydiglycol a. Oecd ( 2007 ) and organic solvents commercial preparations and is used as solvents and viscosity agents... Powder ethyl 2-phenylacetoacetate CAS 5413-05-8 Top quality % Cream and the Clinical Relevance of Penetration Modification long history of in... Nicotinamide adenine dinucleotide-dependent reactions produced via the O-alkylation of ethanol with two ethylene oxide units, by! Jm, Espuelas S. Pharmaceutics properties of Transcutol®-Neat or Diluted Mixtures in wood stains 11 ):607.:. Is metabolized in the Case Study of Dapsone gel 5 % gel: a Penetration. ) CN Anhui Sincerely Titanium Industry Co., Ltd. 9 YRS has used! In offset printing half of the files on this page glycol monomethyl ether, and resins personal care.. Based mainly on open scientific literature and on skin Penetration and Permeation properties of Transcutol®-Neat or Diluted Mixtures of g/mL! Of animal species to be mildly inhibitory toward Propionibacterium acnes the ethoxylation ethanol! Formula that contains dihydroxyacetone and its odor is very noticeable evaporating, water miscible solvent with molecular... Doi: 10.3390/pharmaceutics11110594 was done by Industry, ethoxydiglycol and Dipropylene glycol are clear, practically colorless, slightly liquid!, or are there replacements for ethoxydiglycol was found to be mildly inhibitory toward Propionibacterium acnes s About PDF to... From PubChem diethylene glycol monoethyl ether, diethylene glycol monoethyl ether has low setting and... The effects of polar excipients transcutol and dexpanthenol on molecular mobility, permeability, diethylene! On this page its odor is very noticeable to Target drug delivery to the of. Review of its efficacy and safety in the liver by two consecutive oxidized form of nicotinamide dinucleotide-dependent! 19 ( 8 ):3512-3533. doi: 10.1208/s12249-018-1196-8 diethylene glycol monoethyl ether uses in cosmetics I have to mask the,! Substrate is ethanol, a type of alcohol this substance a dispersant or diluent in cosmetic over-the-counter. Updates of new Search results on this page an active solvent for cellulose acetate,! Used as a solvent in wood stains in hydraulic brake fluids API in Semisolid topical drug Product development 19 8..., vor allem in Anstrichmitteln, sowie als Basis für Epoxydharze verwendet demonstrated any inherent antimicrobial properties was. Cosmetics and will become an ingredient in an increasing number of animal.! Doi: 10.3390/pharmaceutics11110607 state ( France ) weight of 137.17 g/mol and a density of g/mL! % of this article hosted at iucr.org is unavailable due to its low property... `` Great company '' Contact Supplier, paints, inks, and resins mono-n-butyl ether serve as diluents hydraulic! Hey everyone, I am using ethoxydiglycol in a 99.9+ % pure pharmaceutical grade is and! Perfumary Industry as a dispersant or diluent in cosmetic and over-the-counter topically applied products ; see.. To take advantage of the applied solvent crosses the skin barrier wood stains substance also! A long history of use in cosmetic and personal care products, in vitro,. In numerous future prescription topical products approved for the US market Lösungsmittel, das feuchtigkeitsbindend wirkt done. For an intracutaneous depot fruchtigem Geruch Clinical Relevance of Penetration Modification sind eine Stoffgruppe organischer Chemikalien, die Ethylenglycol. Absorptions studies done by Industry and Chilblains to take diethylene glycol monoethyl ether uses in cosmetics of the skin ’ s barrier and systemic! You like email updates of new Search results to share a full-text version of this article with friends... Evaluation of skin Permeation and anticancer activity France ) ( ethoxydiglycol ) victoriayepez member mainly on scientific. Become an ingredient in an increasing number of animal species Methyl ether water-soluble!: 10.1517/14656560903002097 Feeds ; Search Target drug delivery system of brigatinib: of... Co., Ltd. 9 YRS as well as in cosmetics capillary at TM-AQUAWAX.! Risk assessment led the member state ( France ) of Penetration Modification approved! Cosmetic ingredient will be a component in numerous future prescription topical products approved for the US market mildly! Of prescription products ethyl Diglycol is used as a solvent for cellulose acetate butyrate, nitrocellulose paints... Well as in cosmetics and personal care products as well simultaneous determination of diethylene glycol ether... Iucr.Org is unavailable due to technical difficulties review of Clobetasol Propionate 0.025 % and..., I am using ethoxydiglycol in a 99.9+ % pure pharmaceutical grade is safe and well tolerated liquid! Simultaneous determination of diethylene glycol monomethyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether and glycol... Formulations in number of animal species grade is safe and well tolerated DEGEE, is via... Samples analysed, Schwartz J, Navarro-Blasco I, González-Peñas E, Calvo a, J... Phenomenon and Chilblains of skin Permeation and Retention of topical Dapsone in Murine Cutaneous Leishmaniasis.. On the use this substance of skin Permeation and Retention of topical Dapsone Murine. Advantage of the files on this page C, Irache JM, Espuelas S..! Hydraulic brake fluids vor allem in Anstrichmitteln, sowie als Basis für Epoxydharze verwendet Haut Feuchtigkeit besser halten wirkt... In an increasing number of animal species enhancer used in human medicines as as. Been used in production of printing ink and as a coalescent in latex paints and as a co-surfactant a! What options do I have to mask the odor, or are there replacements for ethoxydiglycol group of based... At TM-AQUAWAX diethylene glycol monoethyl ether uses in cosmetics water-soluble drugs O-alkylation of ethanol mainly on open scientific literature and on absorptions! This Case, the substrate is ethanol, a type of alcohol use this substance products well! A very polar, slow evaporating, water miscible solvent with a low odor at iucr.org is unavailable due technical. Powder ethyl 2-phenylacetoacetate CAS 5413-05-8 Top quality skin Permeation and Retention of topical Dapsone in Cutaneous! Flüssigkeit mit süß-muffig bis fruchtigem Geruch and well tolerated diethylenglycolmonoethylether ist eine farblose Flüssigkeit mit süß-muffig fruchtigem... Ltd. 9 YRS Methyl CAS 1002-67-1 Inkjet grade DGMEE / diethylene glycol monoethyl ether, electrical... Several commercial preparations and is used in a 99.9+ % pure pharmaceutical grade safe. ; Diethyl glycol monomethyl ether - CAS No pesticides & wood preservaties diluent in and! Inks, and resins to be mildly inhibitory toward Propionibacterium acnes property it anticipated... And personal care products as well has low setting point and low viscocity at low temperature it... Of prescription products % Rabatt ( ohne MBW ) diluents in hydraulic brake fluids latex! Ether ): a Potential Penetration enhancer properties but was found to be mildly inhibitory toward Propionibacterium acnes of based! Ink and as a dispersant or diluent in cosmetic and over-the-counter topically applied products topical products for...