Moxidectin topical is applied to the skin and is commonly used to prevent heartworms and to treat topical and intestinal parasites. Information contained on this site pertains only to the United States of America, and is not intended to provide adequate information for product use. advantus™ is a flavored soft chew for dogs and puppies 10 weeks of age and older and weighing 4 pounds or greater. Do not give more than one tablet per day. Maximal efficacy of all 3 dosages (99.1 to 100%) was observed at 7 days after treatment. The duration of the course of treatment will, again, depend on the specific condition your vet is prescribing the medicine for. Storage Information: Store at temperatures between 68° and 77°F (20°-25°C). Start to kill adult fleas within 1 hour. Available for Android and iOS devices. Imidacloprid (brand names: advantus®) is an oral medication used to treat flea infestations in dogs. — 85274422 advantus ® has an expiration date you can find on the product label near the barcode. Directions: You should weigh your dog before giving this medication to make sure you are using the right size for your dog. Systemic imidacloprid starts kills fleas within 1 hour, and 97% of fleas are killed within 4 hours. The recommended minimum dose is 4.5 mg/lb (10.0 mg/kg) imidacloprid and 0.45 mg/lb (1.0 mg/kg) moxidectin, once a month, by topical administration. If you have any questions about flea treatment or medical problems associated with flea infestations, consult your veterinarian. Oral dosage forms require careful pharmaceutical formulation. Fleas in your dog’s environment can re-infest your dog. ● advantus™ may be used together with other products, including heartworm preventatives, corticosteroids, antibiotics, vaccines, deworming medications and shampoos. ● advantus™ does not protect against ticks or mosquitoes. Midazolam can be used to stop seizures. Butylhydroxytoluene 1 mg/ml (E 321; as antioxidant). Imidacloprid and its nitrosoimine metabolite (WAK 3839) have been well studied in rats, mice and dogs. Imidacloprid has a wide safety margin in mammals, due to a significantly lower affinity to the nicotinic receptors of vertebrates than those of insects. Side effects are uncommon if used as directed, but vomiting, soft stools, decreased appetite, or difficulty walking may occur. (Lui, 1993; Werner, 1995) The oral LD50 of imidacloprid is 450 mg/kg in rats and 131 mg/kg in mice. Select one or more newsletters to continue. The formulation and dosage schedule are designed to provide a minimum of 4.5 mg/lb (10.0 mg/kg) imidacloprid and 0.45 mg/lb (1.0 mg/kg) moxidectin based on body weight. A review of side effects reported in Australia between 1996 and 2003 found that the most common side effect of using fipronil for dogs was skin irritation or hair loss at the application site. Data sources include IBM Watson Micromedex (updated 6 Jan 2021), Cerner Multum™ (updated 4 Jan 2021), ASHP (updated 6 Jan 2021) and others. Weight of cat [kg] Pipette size to be used Volume [ml] Imidacloprid [mg/kg bw] Dosage schedule for cats: The recommended minimum doses are 10 mg/kg bodyweight imidacloprid and 1.0 mg/kg bodyweight moxidectin, equivalent to 0.1 ml/kg bodyweight Advocate for cats. Every effort has been made to ensure the accuracy of the advantus (imidacloprid) soft chew information published above. Therefore, you may need to treat with advantus™ more than one time. If you suspect an overdose or an adverse reaction to the medication, call your veterinary office immediately. Watch closely to ensure your dog swallows the soft chew. 18 Oral LD 50 values in rats were estimated to be 450 mg/kg for both sexes in one study and 500 and 380 mg/kg in males and females, respectively in another study. Each unit dose (pipette) contains: Unit dose Imidacloprid Moxidectin Advocate for small cats (≤ 4 kg) and ferrets 0.4 ml 40 mg 4 mg Advocate for large cats (> 4–8 kg) 0.8 ml 80 mg 8 mg . Results of a chronic feeding study revealed no adverse effects in dogs given imidacloprid at a dose … The dose of Veraflox ® is 3.4 mg/lb. If your vet prescribes the oral suspension form, then they may advise you to administer it to your cat in doses of 3.4 milligrams per pound of body weight. Do not give more than one tablet a day. However, it remains the responsibility of the readers to familiarize themselves with the product information contained on the US product label or package insert. 5 Cats receiving oral mirtazapine at 1.88 mg q24h and 3.75 mg q24h ingested significantly more food than did cats given placebo. The appetite-stimulating effect of oral mirtazapine was demonstrated in a crossover, blinded trial. ● advantus™ starts to kill fleas within 1 hour. Your vet will adjust the exact dosage based on the precise issue they’re treating. Side effects are uncommon but may include vomiting, soft stools, decreased appetite, or difficulty walking. Adult female fleas feed by ingesting blood from your dog and lay eggs that drop off from your dog’s coat. The following is a guideline for typical use of the drug in cats and must not replace your veterinarian’s advice for your individual pet. Dogs that have abnormally low … Increasing both the dose and the number of dosages of moxidectin improved efficacy, with 100% protection obtained using three dosages of moxidectin at either 40 µg/kg (JYD-34, ZoeMO) or 60 µg/kg (ZoeLA). In animals, midazolam is given as a sedative. Because advantus™ does not have an effect on fleas in the environment, your dog may become re-infested with fleas. * Cats over 18 lbs. Imidacloprid is moderately toxic if ingested. (7.5 mg/kg) body weight once daily for seven consecutive days. Side effects are uncommon, but may include skin irritation at the application site. Side effects are uncommon but may include vomiting, diarrhea, lack of appetite, tiredness, reddening of the skin, or itchiness. Do not use this medication cats, in puppies less than 10 weeks old or weighing less than 4 pounds, or in pregnant or lactating dogs. For additional information for reporting side effects for animal drugs, contact FDA at 1-888-FDA-VETS or online at http://www.fda.gov/AnimalVeterinary/SafetyHealth. A single dose kills adult fleas on your dog. Other Names Imidacloprid, benzyl alcohol This SDS covers the following six products: Advantage for Kittens and Small Cats up to 4kg Advantage for Cats over 4kg Advantage for Puppies and Small Dogs up to 4 kg Advantage for Dogs 4-10kg Advantage for Dogs 10-25kg Call Bayer at 1-800-255-6826. Copyright © 2021 Animalytix LLC. We’re committed to keeping clients and staff safe during COVID-19 with NEW admittance and check-out processes. The following diagram illustrates the flea’s life cycle and where advantus™ works: Fleas reproduce rapidly. If they are not available, follow their directions in contacting an emergency facility. Is there advantus® for cats? The capsule is easy to give to your dog and may be given as an occasional dose when you see fleas on your pet or daily if necessary. Do not use this product on pets less than 8 weeks old, geriatric pets, or sick/weak pets. It is contraindicated in sick, debilitated, or underweight animals. The formulation and dosage schedule are designed to provide a minimum of 4.5 mg/lb (10.0 mg/kg) imidacloprid and 0.45 mg/lb (1.0 mg/kg) moxidectin based on body weight. Advantage Multi ® for Cats (10% imidacloprid + 1% moxidectin) is a colorless to yellow ready-to-use solution packaged in single-dose applicator tubes for topical treatment of cats. Be sure to tell your veterinarian about any medications (including vitamins, supplements, or herbal therapies) that your pet is taking. advantus ® (imidacloprid) 37.5mg 30 ct (large dogs; 23-110 lbs.) If your dog becomes re-infested, you can safely repeat treatment as often as once a day. The treatment schedule should be based on the local epidemiological situation. If a negative reaction occurs, please call your veterinary office. Within days, larvae hatch from these eggs and live undetected in your dog’s surroundings, such as in the carpet and bedding. Fleas in your dog's environment can re-infest your dog, therefore you may need to treat with Advantus more than one time. The acute oral LD 50 of imidacloprid in the rat is in the range of 380–500 mg/kg bw. As specified in the following table, administer the entire contents of the Advantage Multi® for Catstube that correctly corresponds with the body weight of the cat. Use cautiously in debilitated and geriatric dogs. A single dose kills adult fleas on your dog. When these new fleas are seen on your dog, treat with advantus™. Side effects are uncommon but may include lethargy, vomiting, uncoordinated walking, anorexia, diarrhea, and itching. (imidacloprid) soft chew. 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